Bonefos (Clodronate Disodium) Customer Reviews


Rx Prescription Required    RxFormulation : Capsule

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What is Bonefos used for? 

Bonefos, whose generic name is clodronate disodium, belongs to a group of bisphosphonate drugs. It is a highly effective drug that works primarily on bone tissues to prevent bone loss or weakening, reduce bone pain, and lower blood calcium levels. 

This medication is prescribed for people with cancer that has spread to their bones.

How does Bonefos work? 

When you have cancer that has spread to your bones, your bones break down (osteoclast) quicker than your body can restore them. As a result, this causes your blood calcium levels to rise. 

Bonefos tablets work by suppressing the cells responsible for rapid or abnormal bone breakdown with increased osteolysis. Therefore, it decreases elevated calcium levels in the blood, which helps strengthen and increase bone mass, thereby reducing bone fracture incidence.

Bonefos Dosage 

The dosage, strength, and frequency of this drug depend on your medical condition, gender, age, and treatment tolerance. This medication is available in dosages of 400 mg and 800 mg. 

Generally, two Bonefos 800 mg pills are the recommended daily dose for adults to stabilize blood calcium levels and bone destruction (osteolysis) as a single therapy or divided into two doses. 

The initial daily dose for people with hypercalcemia is 2400 mg or 3200 mg. This dosage can be gradually decreased depending on your physician’s evaluation.

What is the best way to use Bonefos? 

It is best to read all prescription directions and information carefully before starting the therapy. Seek medical advice from your healthcare provider or pharmacist if there is anything that you don’t understand about this medicine. 

Clodronate disodium is best taken first thing in the morning on an empty stomach. Consume the whole tablet with a cup of plain water without chewing or crushing the medication. Avoid taking this medication with foods, milk, or other medicines that contain calcium for maximum absorption. Make sure to drink lots of fluid while undergoing this treatment. 

Remember to take this medication regularly to avoid skipping a dosage. Putting a reminder on your calendar can help you remember to take your medicine. If you miss a dose, skip it and continue taking your meds according to your schedule. 

Do not change your dosage. Bear in mind that any alteration in your dose is not advisable.

Bonefos Side Effects 

The following are some of the most common side effects of clodronate disodium that may resolve in time: 

  • Stomach problems (diarrhea, nausea, vomiting) 
  • Stomach pain
  • Loss of appetite
  • Muscle cramps 

You may need to stop taking this medicine and contact your healthcare provider immediately if any of these signs and symptoms worsen over time. Serious side effects include: 

  • Signs and symptoms of possible fracture: pain in the thigh, hip, or groin 
  • Problems in the jaw area: pain, swelling, or numbness
  • Ear pain or infection
  • Fever
  • Symptoms of low calcium levels include muscle spasms, easily irritated, confusion, and numbness in the extremities
  • Skin redness
  • Difficulty breathing

Remember that this list does not include all of the health implications of this drug. Other adverse effects could occur.


Ensure to inform your doctor about your medical history before starting this treatment, especially if you have kidney problems, stomach inflammation, or oral infections. 

Regular blood tests should be taken while using this medication as prescribed by your physician. 

Do not use this drug if you are allergic to clodronate disodium or other ingredients. When using this medicine, you should get medical treatment as soon as you notice any of the following signs and symptoms: rashes, hives, swelling of the face and lips, throat tightness, or difficulty breathing. 

Tell your doctor about any medications you’re taking, including prescriptions, over-the-counter meds, herbal supplements, and vitamins, to avoid drug interaction. 

Notify your doctor if you will undergo invasive dental surgery. Lack of blood supply in the jaw may occur, called osteonecrosis. Report right away if you experience pain, swelling, or inflammation of the jaw. 

To avoid dehydration, increase your fluid intake as much as possible. 

To prevent low calcium levels and strengthen your bones, take enough calcium and vitamin D supplements. 

Keep this drug away from children’s reach and store them accordingly.

How much does Bonefos cost? 

The price of Bonefos is relatively justifiable. Our online pharmacy makes it simple for you to purchase this medication.

Frequently Asked Questions 

Can I lie down right after taking Bonefos? 

When taking Bonefos, you should wait at least 30 minutes before lying down because it has an irritating effect. Failure to do so can result in esophageal irritation or ulcer formation.

Is Bonefos safe during pregnancy? 

Bonefos is not recommended for pregnant women. To avoid harming your child, discuss this treatment with your health care provider. Weigh first the benefits and drawbacks of this medicine.

Can I increase my Bonefos dosage? 

Do not change your dose unless otherwise instructed by your doctor. Talk to your physician about any adjustments. 

Additional information

Generic name:

Clodronate Disodium





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Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Bonefos (Clodronate Disodium). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Bonefos (Clodronate Disodium).