Bonefos (Clodronate Disodium) Customer Reviews


Rx Prescription Required    RxFormulation : Capsule

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Sodium clodronate is used in combination with other drugs to mitigate the breakdown of bone caused by cancer that has metastasized to the bones. It is also employed to treat elevated levels of calcium in the blood, which can be associated with certain cancers. Sodium clodronate functions by slowing down bone loss and reducing the release of calcium from the bones into the bloodstream. This medication falls under the category of drugs known as bisphosphonates.

Uses and Dosage

Take sodium clodronate by mouth without food as prescribed by your doctor, usually 1 to 2 times a day. It should be taken on an empty stomach, either 1 to 2 hours before or 1 to 2 hours after eating. The specific timing may vary depending on the brand you use, so it’s essential to follow the instructions for your particular brand.

Consume sodium clodronate with a full glass of plain water (6 to 8 ounces, 180 to 240 milliliters). Avoid taking it with milk or any other beverage. Swallow the medication whole. After taking it, maintain an upright position (sitting, standing, or walking) and refrain from lying down for at least 30 minutes.

Do not take sodium clodronate simultaneously with food or other medications, as they may hinder its absorption. Take this medication 1 to 2 hours (depending on your brand) before or 1 to 2 hours after any products containing aluminum, calcium, iron, magnesium, or zinc. This includes antacids, certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), quinapril, vitamins/minerals, dairy products (such as milk, yogurt), and calcium-enriched juice.

Stay well-hydrated during the course of treatment with this medication, unless otherwise directed by your doctor.

The dosage is determined by your medical condition and response to treatment. Do not exceed the prescribed amount.

Take this medication regularly to derive the maximum benefit. To help you remember, take it at the same time(s) each day.

Ensure you attend all medical and laboratory appointments so that your doctor can monitor the calcium levels in your blood.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • diarrhea
  • loss of appetite
  • nausea
  • stomach pain
  • vomiting

Inform your healthcare provider immediately if you experience any serious side effects:

  • difficulty breathing
  • wheezing
  • ear pain or discharge from the ear
  • eye infection
  • muscle cramps in the hands, arms, feet, legs, or face
  • red, irritated or swollen eyes
  • new or unusual pain in the hip or thigh
  • pain, swelling, infection, or poor healing of the gums, loose teeth, or numbness of the jaw
  • hives
  • swelling of the throat or mouth
  • severe bone, joint, and/or muscle pain


  • Before taking sodium clodronate, inform your doctor or pharmacist if you have any allergies, especially to bisphosphonates like alendronate, or if you are allergic to any inactive ingredients in the product. Some brands may contain soya lecithin from soybeans, which could be problematic for individuals with soy or peanut allergies.
  • Disclose your medical history to your doctor or pharmacist, particularly if you have kidney disease, difficulty sitting upright or standing for at least 30 minutes, painful swallowing, or issues with the esophagus, stomach, or intestines.
  • Some individuals taking sodium clodronate may experience serious jawbone problems. Your doctor should examine your mouth before initiating this medication. Inform your dentist that you are taking sodium clodronate before any dental procedures.
  • To minimize the risk of jawbone problems, undergo regular dental check-ups and adopt practices to maintain good oral hygiene. If you experience jaw pain, notify your doctor and dentist promptly.
  • Before undergoing any surgery, especially dental procedures, inform your doctor and dentist about your use of this medication and any other products you are taking, including prescription drugs, nonprescription drugs, and herbal products. Your doctor or dentist may advise you to discontinue sodium clodronate before the surgery, so seek specific instructions regarding stopping or starting this medication.
  • Inform your doctor if you are pregnant or planning to become pregnant. Sodium clodronate may persist in your body for an extended period. Pregnancy is not recommended while using sodium clodronate, as it may pose risks to the unborn baby. If you become pregnant, consult your doctor promptly to discuss the risks and benefits of continuing this medication.
  • The passage of this medication into breast milk is unknown. Before breastfeeding, consult your doctor to assess potential risks.

Form and Strength

Bonefos is available in the following forms and strengths:

  • Bonefos capsule:
    • 400 mg


Why should Bonefos be taken on an empty stomach?

Bonefos has a low absorption rate in its oral form. Taking the medication on an empty stomach helps you absorb as much of it as possible.

Can I drink alcohol while taking Bonefos?

No. Alcohol should be avoided while taking this medication as it can increase your risk of severe side effects.



Additional information

Generic name:

Clodronate Disodium





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Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Bonefos (Clodronate Disodium). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Bonefos (Clodronate Disodium).