Chat with us, powered by LiveChat


This transdermal patch is a combination drug that is used to treat hot flashes and vaginal abnormalities that occur during menopause (itching, burning, dryness). Before menopause, this patch is used to address a shortage of estrogen caused by hypogonadism, primary ovarian failure, or surgical ovarian removal. 

Combipatch vs Climara Pro  

  • Both medications are transdermal patches containing a combination of female hormones that are used to treat symptoms of menopause  
  • Combinpatch may also be used to treat vaginal and vulvar changes (itching, burning, drying around the vagina, difficulty urinating, burning sensations) associated with menopause. 
  • Climara is also used to help menopausal women avoid osteoporosis.

Combipatch Doses

CombiPatch 0.05 mg estradiol/0.14 mg NETA per day (9 cm 2) matrix transdermal device is applied twice weekly on the lower abdomen in order to ensure uninterrupted therapy. During a 28-day cycle, a fresh system should be applied to the skin every 3 to 4 days (twice weekly). 

Combipatch Withdrawal Symptoms  

Medicine withdrawal syndrome is common among Combipatch users, particularly among women aged 50 to 59 who have been on the drug for two to five years. Symptoms of withdrawal include: 

  • Suicidal Thoughts 
  • Lability of Affect (emotional incontinence) 
  • Nervousness 
  • Emotional Anxiety 
  • Depression 
  • Pain in the Joints


  • Multiple patches at a time are not recommended. Skin patches should never be cut. 
  • This patch may raise your chances of having a uterine cancer-causing disease. To help reduce this risk, your doctor may prescribe progestin. Any unexpected vaginal bleeding should be reported straight away. 

Combipatch Side Effects  

Potential Side Effects of taking this medication:   

  • Headache 
  • Sun sensitivity is a condition in which a person is sensitive to the sun. 
  • Irritation at the application’s location


  • If you have undetected vaginal bleeding, liver illness, a bleeding problem, are planning major surgery, or had a heart attack, stroke, blood clot, or cancer of the breast, uterus/cervix, or vagina, you should not use this drug. 
  • During pregnancy, do not use it. 
  • This medication may raise your chances of having a disease that leads to uterine cancer. Any unexpected vaginal bleeding should be reported immediately.

Frequently Asked Questions

-What is a Combipatch Alternative?  

There are various alternatives available because this patch is not suited for all. Other forms of combination products and estrogen-only prescriptions are examples of traditional pharmaceuticals. Coping tactics and natural therapies are some of the options. 

-Is it another side effect of Combipatch weight gain?  

Weight gain due to water retention has been observed in women who have been using this patch for two to 5 five years. Other age-related factors also contribute to weight gain. 

-Is Combipatch Weight Loss possible?  

Weight loss has also been observed in women aged 50 to 59 who have been using this patch for two to five years. Some studies showed that estrogen hormone therapy increases the resting metabolism of women which might help slow weight gain 

Generic name:

Estradiol 17b/Norethindrone Acetate




0.05/0.14mg, 0.05/0.25mg

Quantities Available:

8, 24

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Combipatch (Estradiol 17b/Norethindrone Acetate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Combipatch (Estradiol 17b/Norethindrone Acetate).

Shopping Cart
Scroll to Top