Crinone Gel (Progesterone) Customer Reviews

Crinone Gel

Rx Prescription Required    RxFormulation : Gel

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This medication is employed to address infertility in women who do not produce a sufficient amount of a specific natural hormone known as progesterone. Progesterone is crucial for maintaining pregnancy. This medication is also used to reinstate menstrual cycles in women whose cycles have ceased. By providing supplemental progesterone, this medication aims to support fertility, sustain pregnancy, and restore the natural rhythm of menstrual cycles.

Uses and Dosage

This medication is intended for vaginal use exclusively. Remove the wrapper and prepare the applicator according to the provided instructions. If you use this medication at altitudes above 2,500 feet (762 meters), follow additional instructions for preparing the applicator.

For the treatment of infertility, administer this medication as per your doctor’s instructions, usually once or twice a day. If you conceive, continue using this medication for 10-12 weeks as directed, until your body is capable of producing its own progesterone.

If you are using this medication to restore your menstrual cycle, follow your doctor’s instructions, typically using it every other day for a total of up to 6 doses.

If directed to use other vaginal products, ensure a time separation of at least 6 hours between their application and the progesterone gel.

Administer this medication regularly to maximize its benefits. To facilitate adherence, use it at the same time(s) each day.

Avoid increasing your dose or using this drug more frequently or for a more extended period than prescribed. Doing so will not expedite your recovery, but it may elevate the risk of side effects.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • headache
  • breast tenderness, pain, or enlargement
  • gas or bloating
  • stomach pain
  • nausea
  • vomiting
  • constipation
  • diarrhea
  • tiredness
  • drowsiness
  • muscle, joint, or bone pain
  • mood swings
  • irritability
  • vaginal discharge
  • vaginal pain or discomfort
  • changes in sexual desire
  • trouble sleeping

Inform your healthcare provider immediately if you experience any serious side effects:

  • sudden, severe headache
  • dizziness or faintness
  • slow or difficult speech
  • weakness or numbness of an arm or leg
  • lack of coordination or loss of balance
  • shortness of breath
  • sharp chest pain
  • coughing up blood
  • leg swelling or pain
  • loss of vision or blurred vision
  • double vision
  • unexpected vaginal bleeding
  • depression
  • yellowing of the skin or eyes
  • hives
  • rash
  • itching
  • difficulty breathing or swallowing


  • Before using progesterone, inform your doctor or pharmacist if you are allergic to it or have any other allergies. This product may contain inactive ingredients that can cause allergic reactions or other complications.
  • Discuss your medical history with your doctor or pharmacist, especially if you have a history of vaginal bleeding of unknown cause, a personal or family history of cancer, a miscarriage with some tissue remaining in the womb, blood clots, seizures, liver disease, migraines, asthma, heart disease, kidney disease, depression, or diabetes.
  • If you have diabetes, monitor your blood sugar regularly as directed and share the results with your doctor. Notify your doctor promptly if you experience symptoms of high blood sugar, such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
  • This drug may induce drowsiness. Alcohol or marijuana can intensify this effect. Refrain from driving, operating machinery, or engaging in activities requiring alertness until you can do so safely. Limit alcoholic beverages. In general, alcohol is not recommended for pregnant or potentially pregnant women due to the increased risk of harm to the baby.
  • This medication may be used during pregnancy as directed by your doctor. Consult your doctor for more details.
  • This drug passes into breast milk. Consult your doctor before breastfeeding.

Form and Strength

Crinone Gel is available in the following forms and strengths:

  • Crinone Gel gel:
    • 8 %


Do I have to lie down after using Crinone?

No. You have to be lying down to properly insert Crinone, but once you’ve finished applying the medication, you can get up.

What time of the day should I use Crinone?

If you are only using Crinone once a day or once every other day, you can apply it whenever is most convenient as long as you use it around the same time of the day.



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Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Crinone Gel (Progesterone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Crinone Gel (Progesterone).