Cuprimine for Pet (Penicillamine) Customer Reviews

Cuprimine for Pet

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Penicillamine is primarily used in dogs and cats to treat liver disease caused by copper buildup. Additionally, it is employed to manage lead poisoning as well as bladder and kidney stones. As a chelating agent, penicillamine helps treat conditions resulting from heavy metal poisoning by eliminating copper, iron, lead, or other metals from the body. Although penicillamine is derived from penicillin, a common antibiotic, it does not possess antibiotic properties.

Uses and Dosage

This medication should never be administered without first consulting your veterinarian.

Penicillamine is best absorbed when given on an empty stomach, at least 30 minutes before a meal, as food can significantly reduce the amount of medication absorbed into the body.

For copper-related toxicity, Penicillamine is typically dosed at 5 to 7 mg per pound (15 mg/kg) orally, twice daily.

In cases of lead poisoning, the daily dosage of Penicillamine ranges from 15 to 50 mg per pound (30 to 110 mg/kg). This total dose is divided into three to four doses throughout the day and is closely supervised by a veterinarian.

Penicillamine is usually administered for several weeks to months, and some animals may require an even longer treatment course. The duration of administration depends on the condition being treated, the response to the medication, and the development of any adverse effects.

Be sure to complete the prescription unless your veterinarian specifically directs otherwise. Even if your pet feels better, the entire treatment plan should be finished to prevent relapse.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • vomiting
  • nausea
  • diarrhea

Inform your healthcare provider immediately if your pet experiences any serious side effects:

  • decreased appetite
  • fever
  • swollen lymph nodes
  • skin rash, hives, and itching
  • kidney issues


  • Penicillamine should not be used in pets with certain medical conditions, such as kidney disease, the presence of lead in their gastrointestinal tract, or hypersensitivity to penicillin.
  • Administering penicillamine alongside certain medications can pose health risks to your pet. Discuss all of your pet’s medications, including vitamins and supplements, and their medical conditions with your veterinarian.
  • Penicillamine may cause birth defects and should be used with caution in pregnant or nursing pets.
  • Penicillamine can lead to low levels of essential vitamins and minerals such as zinc, iron, copper, calcium, and pyridoxine (vitamin B6). Your vet may recommend adding supplements to their diet during treatment.
  • During treatment, your veterinarian will perform specific blood and urine tests to monitor how well penicillamine is working, as well as to evaluate the immune system function and the effects of the drug on the liver and kidneys.
  • Additional monitoring may be recommended depending on your pet’s individual needs, other medications they may be taking, or the condition that initially required the use of this medication.

Form and Strength

  • Cuprimine for Pet is available in the following forms and strengths:
    • Cuprimine for Pet


How long does it take for Cuprimine to work in dogs?

It may require weeks to months of treatment for Cuprimine to work in dogs.

Can I get Cuprimine over the counter?

No. Cuprimine is only available via prescription from your veterinarian, usually after a medical inspection of your pet.



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Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Cuprimine for Pet (Penicillamine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Cuprimine for Pet (Penicillamine).