Divigel (Estradiol Gel) Customer Reviews


Rx Prescription Required    RxFormulation : Gel Sachet

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Estradiol gel is a female hormone (estrogen) that comes as a transparent, odorless, and colorless gel.  It is prescribed to help reduce symptoms of menopause such as hot flashes, vaginal dryness, burning, and irritation caused by the body producing less estrogen. 

Divigel vs Estrogel  

  • Divigel is a drug that comes in packets and is administered to the upper thigh of your right or left leg. EstroGel is given to your entire arm using a pump, and application can be messy and difficult to follow. Both prescriptions should be taken at the same time every day. 
  • Both drugs relieve menopausal hot flashes and vaginal dryness. 
  • Both estrogen replacement therapies are associated with side effects like uterine cancer and breast cancer.  Thus, risks and benefits should be thoroughly discussed with your doctor before starting treatment.

Divigel and Hair Loss

Hair loss is common among women going through menopause due to hormonal changes. The use of this medication as hormone replacement therapy to treat menopausal symptoms may also be a good treatment for hair loss. 

Divigel Doses

Administration & Dosing 

  • This gel comes in three different doses: 0.25 mg, 0.5 mg, and 1.00 mg estradiol per day. 
  • Estradiol may enhance your chances of acquiring uterine cancer. To reduce this risk, your doctor may also prescribe progestin while taking estradiol. Any unexpected vaginal bleeding should be reported immediately. 
  • Read all information, prescription, and instruction sheets given. Discuss with your doctor or pharmacist if you have any concerns. 

Divigel Side Effects 

The most common side effects are as follows: 

  • Breast discomfort; 
  • Headache; 
  • Vaginal bleeding, spotting, itching or discharge, changes in monthly cycles; 
  • Thinning hair; or 
  • Nausea, bloating, and stomach cramps.


  • Divigel should not be used if you are pregnant. 
  • Estradiol may enhance chances of acquiring uterine, ovarian, or breast cancer. Immediately report any unexpected vaginal bleeding. 
  • This prescription drug may raise the risk of blood clots, stroke, or heart attack. Estradiol is not recommended to prevent heart disease, stroke, or dementia. 
  • Estradiol topical is absorbed via the skin and can produce negative effects in kids who come into contact with affected skin. 

Frequently Asked Questions  

-Does Divigel help with weight loss?  

Yes, one of this medication’s negative effects is a decrease in appetite, resulting in weight reduction. 

-Is there a link between Divigel and weight gain? 

Weight gain has been observed in some Divigel users, particularly females aged 60 and over who have been taking the medicine for 6 to 12 months. 

-Is the use of Divigel and Anxiety side effects possible?  

Some people using this drug might experience negative psychological symptoms, including anxiety and depression.  There are studies linking anxiety symptoms to low levels of the female sex hormones such as estrogen. Best to consult your doctor if you experience anxiety while using Divigel. 

Additional information

Generic name:

Estradiol Gel


Gel Sachet


0.5mg, 0.25mg, 1mg

Quantities Available:

30 sachets, 90 sachets

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Divigel (Estradiol Gel). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Divigel (Estradiol Gel).