Fosamax Plus D (Alendronate/Vitamin D3) Customer Reviews

Fosamax Plus D

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Generic alternative for Fosamax Plus D

Alendronate/Vitamin D3

Rx Prescription Required    RxFormulation : Tablet

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This medication is prescribed to address osteoporosis and to enhance bone density. Osteoporosis leads to a thinning of bones and an increased susceptibility to fractures. This product is a combination of two drugs: alendronate and cholecalciferol (vitamin D3). Alendronate functions by slowing down bone loss, thereby aiding in the maintenance of robust bones and reducing the likelihood of fractures. It belongs to a category of medications known as bisphosphonates. Vitamin D3 facilitates the absorption of calcium in the body and is essential for the formation of sturdy bones.

Uses and Dosage

Typically, this medication is taken once a week, unless your doctor advises otherwise. Choose a day of the week that aligns with your schedule and adhere to that specific day for each weekly dose.

Administer this medication orally upon waking and before consuming your first meal, drink, or any other medication.

Swallow the tablet whole with a full glass (6-8 ounces or 180-240 milliliters) of plain water. Avoid chewing or sucking on the tablet. Subsequently, maintain an upright position (sitting, standing, or walking) for a minimum of 30 minutes, refraining from lying down until after your first meal of the day. This product is effective only when taken on an empty stomach. Wait at least 30 minutes (preferably 1 to 2 hours) after ingestion before consuming anything other than plain water.

Avoid taking this medication at bedtime or while still in bed, as absorption may be compromised, potentially leading to side effects.

Several medications can hinder the absorption of this product, including quinapril, specific forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), sucralfate bismuth subsalicylate, mineral oil, orlistat, cholestyramine, and colestipol. Additionally, certain supplements and foods may interfere with absorption, such as calcium or iron supplements, vitamins with minerals, antacids, olestra, dairy products (like milk, yogurt), mineral water, coffee, tea, and calcium-enriched juice. Refrain from consuming these products for at least 30 minutes (preferably 1 to 2 hours) after taking this medication.

Consistency is crucial for reaping the maximum benefits of this medication. Remember to take it on the same day each week, and consider marking your calendar as a helpful reminder. Discuss with your doctor the potential risks and benefits associated with the long-term use of this medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • acid or sour stomach
  • belching
  • constipation
  • excess air or gas in the stomach or intestines
  • full feeling
  • headache
  • indigestion
  • passing gas
  • pressure in the stomach
  • stomach discomfort, upset, or pain
  • swelling of the abdominal or stomach area

Inform your healthcare provider immediately if you experience any serious side effects:

  • chest pain, discomfort, or burning
  • difficulty with swallowing
  • heartburn
  • muscle or bone pain
  • pain with swallowing
  • vomiting blood


  • Prior to taking alendronate/vitamin D3, inform your doctor or pharmacist about any allergies you may have, whether to this medication, other bisphosphonates, other vitamin D products, or any other substances present in the product. Inactive ingredients in the medication could potentially trigger allergic reactions or other complications.
  • Before initiating this medication, share your medical history with your doctor or pharmacist, especially if you have conditions such as esophageal disorders, difficulty swallowing, challenges maintaining an upright position for at least 30 minutes, low calcium levels, kidney issues, or stomach/intestinal disorders (e.g., ulcers).
  • Serious jawbone problems may occur in some individuals taking alendronate/vitamin D3. It is advisable for your doctor to examine your mouth before starting this medication. Inform your dentist about your medication before undergoing any dental procedures. To minimize the risk of jawbone problems, schedule regular dental check-ups, and educate yourself on maintaining optimal dental hygiene. If you experience jaw pain, promptly notify your doctor and dentist.
  • This drug is not recommended for use in children, as studies have revealed severe side effects such as vomiting, fever, and flu-like symptoms in many children who took this medication.
  • If you are pregnant or planning to become pregnant, inform your doctor. Alendronate may persist in your body for an extended period, and pregnancy is not advised while using this medication. Discuss the potential risks and benefits with your doctor.
  • The cholecalciferol (vitamin D3) in this medication passes into breast milk, while it is uncertain if alendronate passes into breast milk. Consult your doctor before breastfeeding to ensure a thorough understanding of the potential risks and benefits.

Form and Strength

Fosamax Plus D is available in the following forms and strengths:

  • Fosamax Plus D tablet:
    • 70 mg / 5600 IU
  • alendronate and vitamin D3 tablet:
    • 70 mg / 2800 IU


Can you use Fosamax Plus D to treat vitamin D deficiency?

Even though there’s vitamin D in Fosamax Plus D, it shouldn’t be used to treat vitamin D deficiency. If you’re vitamin D deficient, you might need a much higher dose of vitamin D than what’s in this medication.

Does Fosamax Plus D cause weight gain?

Weight gain isn’t a side effect that you should have while taking Fosamax Plus D.



Additional information

Generic name:

Alendronate/Vitamin D3




70mg/2800IU, 70mg/5600IU

Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Fosamax Plus D (Alendronate/Vitamin D3). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Fosamax Plus D (Alendronate/Vitamin D3).