Lupron Depot for Endometriosis

Lupron Depot belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) antagonists. It is used to reduce the human body’s production of specific hormones, natural chemicals that influence the behavior of certain cells. Because Lupron Depot can reduce the production of both male and female hormones, it is used to treat specific conditions in men, women, and children. The manufacturer performed no clinical trials of this drug on birds and makes it clear that veterinarians are prescribing it ‘off label’ something that is commonly done with most human drugs that are used on animals.

This medicine is generally prescribed in women to treat endometriosis. Lupron lowers estrogen levels, which can lead to a decrease in bone compactness in both men and women. Decreased bone compactness could increase your risk of osteoporosis, or easily broken bone disease, later in life. Accordingly, the drug is not usually given for longer than 6 months at a time.

How is Lupron administered?

It is given by injection once a month, every 3 months, or every 4 months, depending on the form you’ve been prescribed. Lupron is to be administered by a trained healthcare professional.

Women who miss their monthly injections of Lupron Depot may experience resumption of menstrual bleeding.

Who can not use Lupron?

It should not be taken if you are:

  • Pregnant
  • Breast-feeding
  • Experiencing undiagnosed, abnormal vaginal bleeding

Side effects of Lupron

Seek medical help if you experience these SEVERE side effects.

  • (Women) Agitation
  • Allergic reactions
  • Blood clots
  • Bruising
  • Delusions
  • Difficult or painful urination
  • Dry mouth
  • Ear pain
  • Eye problems
  • Facial swelling
  • Fainting
  • Hair loss
  • Hair problems
  • Palpitations (throbbing heartbeat)
  • Rapid heartbeat

Contact your doctor if these COMMON side effects persist or worsen.

  • (Women) Anxiety
  • Appetite changes
  • Breast tenderness or pain
  • Depression
  • Fluid retention
  • Development of male characteristics
  • Dizziness
  • General pain
  • Inflammation of the vagina (vaginitis)
  • Insomnia or other sleep disorders
  • Joint pain
  • Memory problems
  • Nausea and vomiting
  • Nervousness
  • Skin reactions
  • Stomach or intestinal disorders
  • Unusual burning or prickling sensation of the skin
  • Weakness
  • Weight gain or loss
    • (Men) Breathing problems
    • Dizziness/vertigo
    • Fluid retention
    • Headache
    • Hot flashes
    • Impotence
    • Sleep disorders
    • Joint disorders
    • Nausea
    • Pain
    • Skin reaction
    • Stomach and intestinal disorder
    • Sweats
    • Testicle shrinking
    • Urinary problems
    • Vomiting
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