Premarin Vaginal Cream (Conjugated Estrogen) Customer Reviews

Premarin Vaginal Cream

Rx Prescription Required    RxFormulation : Cream

StrengthQuantity & PriceBuy Now
Buy Now
norton image

We don't sell this generic-version medication.

norton image

We are Certified



Vaginal estrogen is utilized to alleviate vaginal dryness, itching, and burning, as well as painful or difficult urination, and sudden urge to urinate in women who are experiencing or have experienced menopause. It is also effective in treating hot flushes or sudden sensations of heat and sweating in menopausal women.

Vaginal cream is another option that is used to treat a condition called kraurosis vulvae, which may cause vaginal dryness and discomfort in women or girls of any age. Estrogen falls into the category of hormone medications and functions by replacing the estrogen that the body normally produces.

Uses and Dosage

Follow your doctor’s instructions when using this medication. Prepare the applicator according to the directions and fill it with the prescribed amount of medication. Insert the applicator high into the vagina and push the plunger to release the medication.

Clean the applicator thoroughly with warm soapy water and rinse it well. Avoid boiling or using hot water to clean the applicator.

The appropriate dosage will depend on your medical condition and your response to treatment. Take the medication regularly according to your dosing schedule to obtain the maximum benefit. Do not exceed the recommended dosage or use the medication more frequently or for a longer period than prescribed.

Notify your doctor if your condition fails to improve or worsens while taking this medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • breast pain or tenderness
  • nausea
  • headache
  • vomiting
  • diarrhea
  • difficulty falling asleep or staying asleep
  • changes in sexual desire
  • hair loss
  • spotty darkening of the skin on the face
  • sudden feelings of heat or sweating
  • stomach pain or bloating
  • swelling, redness, burning, itching, or irritation of the vagina
  • vaginal discharge
  • painful or difficult urination
  • back or joint pain
  • runny nose or congestion

Inform your healthcare provider immediately if you experience any serious side effects:

  • bulging eyes
  • ongoing pain that begins in the stomach area but may spread to the back nausea, vomiting, or loss of appetite
  • rash, hives, itching, hoarseness, or difficulty breathing or swallowing
  • swelling of the eyes, face, tongue, throat, hands, arms, feet, ankles, or lower legs
  • fever, nausea or vomiting
  • diarrhea
  • muscle pain
  • dizziness or fainting
  • rash on face or body


Prior to using this medication, inform your healthcare provider or pharmacist if you have allergies to this medication or any other substances. This medication may contain inactive ingredients that can cause allergic reactions or other problems.

Prior to using this medication, inform your healthcare provider or pharmacist about your medical history, especially if you have: vaginal bleeding of unknown cause, specific cancers, blood clots, stroke, heart disease, liver disease, kidney disease, family medical history (particularly breast lumps, cancer, blood clots), family or personal history of swelling disorder (angioedema), blood clotting disorders, high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalances, a certain hormone problem (hypoparathyroidism), uterus problems, gallbladder disease, asthma, seizures, migraine headaches, mental/mood disorders, or certain blood disorders (porphyria).

Do not smoke or use tobacco while taking this medication. Smoking in combination with estrogens raises your risk of stroke, blood clots, high blood pressure, and heart attack, particularly in women aged 35 years and older.

Inform your healthcare provider if you have recently had surgery, will undergo surgery, or will be confined to a chair or bed for an extended period, such as a long flight. These circumstances raise your risk of blood clots, particularly if you are using an estrogen product. You may need to pause taking this medication for a period or take extra precautions.

This medication may cause dark, blotchy patches on your skin and face (melasma). Sun exposure can aggravate this effect. Limit your exposure to the sun, avoid tanning booths and sunlamps, and use sunscreen and protective clothing when outdoors.

If you are nearsighted or use contact lenses, you may experience vision difficulties or problems wearing your contact lenses. Contact your eye doctor if you experience these issues.

Certain estrogen products contain mineral oil, which may weaken rubber products such as latex condoms, cervical caps, and diaphragms, causing them to fail. Consult your pharmacist if you are uncertain whether your product includes mineral oil.

This medication should not be used during pregnancy. If you become pregnant or believe you may be pregnant, inform your healthcare provider immediately.

This medication is excreted in breast milk and may reduce the quality and quantity of breast milk produced. Consult your doctor before breastfeeding.

Form and Strength

Premarin Vaginal Cream is available in the following forms and strengths:

  • Premarin Vaginal Cream cream:

    • 0.625mg


Will Premarin Vaginal Cream affect my husband?

Premarin Vaginal Cream or other vaginal creams should not be used right before sex because the partner may absorb the estrogen hormone through their skin.

How long does it take Premarin Vaginal Cream to start working?

You may get relief as soon as 4 weeks.



Additional information

Generic name:

Conjugated Estrogen





Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Premarin Vaginal Cream (Conjugated Estrogen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Premarin Vaginal Cream (Conjugated Estrogen).