Prescription Required 
Formulation : 
Description
Indications
Combinations of estrogen and progestin are utilized to alleviate specific symptoms associated with menopause. Estrogen, and progestin, are integral to the female reproductive system. Hormone replacement therapy functions by supplementing the estrogen hormone that the body no longer produces naturally. Estrogen is effective in diminishing sensations of warmth in the upper body, episodes of sweating and heat (hot flashes), as well as addressing vaginal symptoms such as itching, burning, and dryness. In hormone replacement therapy, progestin is combined with estrogen to mitigate the risk of uterine cancer in women who retain their uterus.
Uses and Dosage
Consume this medication orally, with or without food, as instructed by your doctor, typically once daily. To prevent stomach upset, you can take it with food or immediately after a meal.
The prescribed dosage is determined by your medical condition and how you respond to the treatment.
For optimal benefits, take this medication consistently and at the same time each day.
Adhere to your dosing schedule diligently, avoiding any increase in dosage or taking the medication more frequently or for a longer duration than directed.
Inform your doctor if there is no improvement in your condition or if it worsens.
Side Effects
Some side effects may occur that usually do not need medical attention:
- headache
- upset stomach
- vomiting
- stomach cramps or bloating
- diarrhea
- appetite and weight changes
- changes in sex drive or ability
- nervousness
- brown or black skin patches
- acne
- swelling of hands, feet, or lower legs (fluid retention)
- bleeding or spotting between menstrual periods
- changes in menstrual flow
- breast tenderness, enlargement, or discharge
- difficulty wearing contact lenses
Inform your healthcare provider immediately if you experience any serious side effects:
- double vision
- severe abdominal pain
- yellowing of the skin or eyes
- severe mental depression
- unusual bleeding
- loss of appetite
- rash
- extreme tiredness, weakness, or lack of energy
- fever
- dark-colored urine
- light-colored stool
Caution
- Before initiating this medication, inform your doctor or pharmacist about any existing allergies you may have, as this product could contain inactive ingredients that might trigger allergic reactions or other complications.
- Discuss your medical history with your doctor or pharmacist before using this medication, especially if you have experienced vaginal bleeding of unknown origin, certain cancers (such as breast cancer, uterine/ovarian cancer), blood clots, stroke, heart disease, liver disease, kidney disease, a family history of medical conditions (particularly breast lumps, cancer, blood clots), a family or personal history of a specific swelling disorder (angioedema), blood clotting disorders, high blood pressure, diabetes, high blood cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalances, a particular hormone problem (hypoparathyroidism), uterus issues, gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), or mental/mood disorders.
- Avoid smoking or using tobacco while using this medication, as the combination of estrogens and smoking heightens the risk of stroke, blood clots, high blood pressure, and heart attack, especially in women over the age of 35.
- Notify your doctor if you have recently undergone or are planning to undergo surgery or if you will be immobile for an extended period (e.g., a long plane flight). Such conditions increase the risk of blood clots, particularly when using estrogen products. Your doctor may advise temporary discontinuation of the medication or special precautions.
- Be aware that this medication may cause blotchy, dark areas on the face and skin (melasma). Sun exposure can exacerbate this effect, so limit your time in the sun, avoid tanning booths and sunlamps, and use sunscreen and protective clothing when outdoors.
- If you are nearsighted or wear contact lenses, you may experience vision problems or difficulty wearing your contact lenses. Contact your eye doctor if such issues arise.
- This medication should not be used during pregnancy. If you become pregnant or suspect pregnancy, inform your doctor promptly.
- As this medication passes into breast milk and may impact the quantity and quality of breast milk produced, your doctor should be consulted before breastfeeding.
Form and Strength
Prempro Low Dose is available in the following forms and strengths:
- Prempro Low Dose tablet:
- 1.5 / 0.3 mg
FAQ
Are Premarin and Prempro Low Dose the same?
No. Premarin only includes conjugated estrogens. Prempro includes both conjugated estrogens and medroxyprogesterone.
How long should you take Prempro?
Prempro, like all estrogen replacement medications, raises your risk of some serious medical problems (such as breast cancer and blood clots) when used for long periods of time. The longer you are using this medication, the higher your risk is, so it’s recommended to only use this medication for the shortest amount of time necessary.
Resources
- https://www.goodrx.com/prempro/what-is
- https://www.mayoclinic.org/drugs-supplements/conjugated-estrogens-and-medroxyprogesterone-oral-route/description/drg-20075469
- https://medlineplus.gov/druginfo/meds/a601041.html
- https://www.webmd.com/drugs/2/drug-5365/prempro-oral/details
- https://www.drugs.com/cons/prempro-low-dose.html
