Vagifem Vaginal Tablet (Estradiol) Customer Reviews

Vagifem Vaginal Tablet

Rx Prescription Required    RxFormulation : Vaginal Tablet

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Drug Description:

Vagifem (estradiol) vaginal tablet is a prescription medicine used to treat dryness, burning, and irritation of the vagina (atrophic vaginitis) caused by menopause. It could either be used alone or with other medications to replenish estrogen lost during menopause.

This drug’s mechanism of action is reducing the elevated levels of gonadotropins, luteinizing hormone, and follicle-stimulating hormone in post-menopausal women through a negative feedback mechanism. Thus, it maintains the equilibrium of the female reproductive system and secondary sexual characteristics.


Before starting to use Vagifem tablets, make sure to read the medication and prescription guide provided. Use it as prescribed by your physician. This is available in Vagifem 10mcg and Vagifem 25mcg tablets.

Use this medication regularly and as directed by your physician to achieve full benefits. Do not increase or decrease your dose unless advised by a healthcare provider. Follow a dosing schedule to avoid missing a dose.

Here are the steps in using Vagifem vaginal tablet:

  1. Wash and dry your hands thoroughly before using Vagifem.
  2. Tear off the applicator pack to open. Take the applicator out of the plastic pack and hold it in a way that the index finger of your dominant hand can push the plunger.
  3. Assume a comfortable position for the insertion of Vagifem. Using your other hand, guide the applicator and insert it gently and slowly inside the vaginal opening. To ensure that the applicator is adequately inserted, at least half of the applicator should be inside the vagina.
  4. Note: If the tablet falls out during insertion, discard it and use another tablet-filled applicator.

  5. Once the applicator has been inserted, gently push the plunger until it is fully depressed. This will eject the tablet inside your vagina.
  6. Gently remove the applicator and discard it properly.

Side Effects

Some of the common Vagifem side effects are:
-stomach cramps
-breast tenderness
-weight changes
-increased facial hair

Most of these Vagifem side effects are mild and would disappear after a few days. However, if the side effects worsen or if you experience severe adverse reactions, you may have to consult your physician or any healthcare provider immediately. Some serious side effects to look out for are unusual vaginal bleeding, breast lumps, severe stomach pain, persistent vomiting, severe headache, chest pain, weakness, or mood changes.


Avoid using Vagifem tablet if you have a known allergy to estradiol or any other ingredients this drug may have. Signs of an allergic reaction are red patches, hives, persistent dizziness, and difficulty breathing. Discontinue medication and seek emergency help if you suspect an allergic reaction.

Talk to your doctor about any medical condition you have or have a history of cancer, blood clots, stroke, heart disease, liver disease, kidney disease, hypertension, diabetes, mineral or hormonal imbalance, gallstones, seizure, or any blood disorder. Some medical conditions and some medications you are taking may affect how your body responds to this medication.

Avoid using tobacco and other similar substances that could increase the risk of developing blood clots, stroke, hypertension, and heart attack. Additionally, talk to your doctor if you will be undergoing surgery or going on a long-haul flight. Staying on a bed or in a chair, with minimal movements, for a long time may also make you more prone to blood clots.

Limit your time under direct sunlight as it could aggravate the dark spots or freckles on the face caused by this drug. If going outdoors, apply sunscreen or wear protective accessories like a cap. Avoid indoor tanning as well.

Frequently Asked Questions

Is Vagifem safe?
Multiple studies show that Vagifem vaginal tablet is safe and effective.

What are the common side effects of Vagifem?
Common side effects of Vagifem weight gain, headache, bloating, breast swelling. You may refer to the Side Effects section for more information.

Can Vagifem vaginal tablet help with hot flashes?
Vagifem is an estrogen therapy that only addresses localized symptoms.

Can I buy Vagifem no prescription?
Vagifem is a prescription medicine. Thus, a prescription from a healthcare professional is required.

How much does a Vagifem vaginal tablet cost?
You can check the price of Vagifem at the top portion of this page. If you have more questions about this vaginal tablet, you may contact us.

Additional information

Generic name:



Vaginal Tablet



Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Vagifem Vaginal Tablet (Estradiol). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Vagifem Vaginal Tablet (Estradiol).