Ziac (a combination of Hydrochlorothiazide and Bisoprolol) is used to treat high blood pressure (hypertension). By lowering high blood pressure, strokes, heart attacks, and kidney problems can be prevented.

Ziac is the product of Bisoprolol and Hydrochlorothiazide. Hydrochlorothiazide is a water pill, also known as thiazide diuretic, which helps prevent fluid retention caused by your body absorbing too much salt. It works by increasing the amount of urine your body produces to get rid of the extra salt. As a result, the blood vessels will be relaxed for better blood flow. Bisoprolol is from the class of medicine known as the beta blocker. It blocks the effect of some natural chemicals such as epinephrine in the heart and blood vessels slowing the heartbeat, lowering blood pressure, and reducing strain on the heart.

Before using Ziac, tell your doctor if you are allergic to Ziac or to any drugs, you are pregnant or plan to become pregnant or are breast-feeding a baby during treatment. Tell your doctor about all the prescription and over-the-counter medications, vitamins, minerals and herbal products that you use. Also, let your doctor know if you have the following medical problems: kidney or liver disease, bronchospastic lung disease, cirrhosis, asthma, allergies, gout, lupus, diabetes, a thyroid disorder, congestive heart failure, and blood circulation problems.

Do not use Ziac if you are/have:

  • Severe or uncontrolled heart failure
  • A heart condition called “sick sinus syndrome” or “AV block” (2nd or 3rd degree)
  • You are unable to urinate
  • You are allergic to sulfa drugs

Precaution, while using Ziac:

  • Ziac does not control high blood pressure.
  • Ziac may cause heart failure or may cause changes in your blood sugar levels.
  • Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
  • If you are diabetic, check your blood sugar carefully. Using bisoprolol can increase difficulty in detecting low blood sugar.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are using Ziac.
  • Do not stop using Ziac suddenly, or you could have a serious or life-threatening heart problem.
  • Your blood pressure, urine and blood test will need to be checked on a regular basis.
  • Avoid drinking alcohol.
  • Avoid becoming overheated or dehydrated during exercise and in hot weather.
  • Ziac may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
  • Avoid using other medicines that make you light-headed (especially narcotic pain medication or barbiturates). They can add to the side effects of Ziac.

How do you take Ziac?

Follow the directions on the label of your medication and take Ziac as prescribed by your doctor. You can take this medication with or without food. Avoid taking this medication within 4 hours before you sleep to prevent you from getting up to urinate. Do not stop taking this medication unless you have been advised by your doctor. Do not overdose on this medication. If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue on your regular dosing schedule.

What are the side effects

Serious side effects:

Swelling, rapid weight gain, feeling short of breath, even with mild exertion; Fast, slow, or uneven, heartbeat; Chest pain; easy bruising or bleeding; Sudden numbness or weakness on one side of the body, problems with vision or speech, chest pain, or Pain in one or both legs; Numbness or tingly feeling in your hands or feet; Feeling weak, drowsy, restless, or light-headed; nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions); increased urination, leg discomfort, muscle pain or weakness or limp feeling; urinating less than usual or not at all; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects:

Diarrhea, constipation, upset stomach; headache, tired feeling; dizziness, spinning sensation; cough, runny nose; ringing in your ears; or blurred vision.

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