Anafranil (Clomipramine) Customer Reviews


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Generic alternative for Anafranil


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Clomipramine is prescribed for the treatment of Obsessive-Compulsive Disorder (OCD). Its therapeutic effects are attributed to the reduction of unwanted, persistent thoughts (obsessions) and the mitigation of the compulsion to engage in repetitive behaviors (such as hand-washing, counting, or checking) that impede daily functioning.

Clomipramine belongs to a class of medications known as tricyclic antidepressants, which exert their effect by restoring the equilibrium of certain endogenous neurotransmitters, including serotonin, within the brain.

Uses and Dosage

Clomipramine is administered orally in the form of capsules. Typically, during the initial stages of treatment, the medication is taken three times daily with meals to allow for proper adjustment of the body to the drug. After a few weeks of therapy, the medication is typically taken once daily at bedtime.

Adhere to the instructions on the prescription label and seek clarification from the physician or pharmacist on any unclear directions. Clomipramine should be taken exactly as prescribed, and the dosage should not be increased, decreased, or taken more frequently than directed by the physician.

The dosage of clomipramine may start at a low level and gradually increase over time as determined by the physician.

It may take several weeks or longer for the full therapeutic effects of clomipramine to become apparent.

Even if the patient begins to feel better, continue taking the medication as prescribed. Abruptly stopping clomipramine use can result in withdrawal symptoms, such as dizziness, nausea, vomiting, headache, weakness, sleep disturbances, fever, and irritability.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • blistering, crusting, irritation, itching, or reddening of the skin
  • change in taste
  • constipation
  • cracked, dry, or scaly skin
  • change in interest in sexual intercourse
  • diarrhea
  • dry skin
  • heartburn
  • inability to have or keep an erection
  • increased interest in sexual intercourse
  • joint pain or swelling
  • pimples
  • redness of the face, neck, arms, and occasionally, upper chest
  • shakiness in the legs, arms, hands, or feet
  • stomach discomfort, upset, or pain
  • swelling
  • trembling or shaking of the hands or feet
  • absent, missed, or irregular menstrual periods
  • breast pain

Inform your healthcare provider immediately if you experience any serious side effects:

  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • confusion
  • difficult, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • excessive muscle tone
  • fear or nervousness
  • feeling sad or empty
  • fever
  • hearing changes
  • hives or welts, skin rash
  • irritability
  • lower back or side pain
  • muscle stiffness, tension, or tightness
  • poor concentration
  • rhythmic movement of muscles
  • sneezing
  • tightness of the chest
  • trouble breathing
  • unusual tiredness or weakness
  • voice changes


Prior to taking clomipramine, inform your healthcare provider of any allergies you may have, particularly if you have had an allergic reaction to other tricyclic antidepressants such as imipramine or nortriptyline, or if you have any other allergies. This medication may contain inactive ingredients that could trigger an allergic reaction or other complications.

Prior to using this medication, be sure to disclose your medical history to your healthcare provider or pharmacist, particularly if you have a history of bleeding disorders, blood disorders such as purpura or thrombocytopenia, respiratory issues such as asthma or chronic bronchitis, a personal or family history of glaucoma of the angle-closure type, eating disorders such as bulimia, heart problems such as arrhythmias, coronary artery disease or recent heart attack, intestinal issues such as chronic constipation or ileus, liver or kidney problems, personal or family history of other mental/mood conditions, heartburn or stomach acid in the esophagus such as due to hiatal hernia, seizures, overactive thyroid (hyperthyroidism), difficulty urinating (urinary retention, enlarged prostate), any condition that may increase the risk of seizures such as alcohol or sedative dependency, use of electroconvulsive therapy, brain injury/disease or certain types of tumors such as pheochromocytoma or neuroblastoma.

Clomipramine may cause QT prolongation, a condition that affects the heart rhythm. QT prolongation can rarely result in serious (and rarely fatal) fast/irregular heartbeat and other symptoms such as severe dizziness or fainting which require immediate medical attention.

This medication may cause dizziness or drowsiness or temporarily blur your vision. Alcohol or marijuana can increase these side effects. Do not drive, operate machinery, or engage in any activity that requires alertness or clear vision until you can do so safely.

Older adults may be more susceptible to the side effects of this medication, particularly bleeding, confusion, dizziness, and QT prolongation. Dizziness and confusion can increase the risk of falling. Older adults may also be at greater risk of developing low sodium in their blood, particularly if they are taking diuretics.

During pregnancy, this medication should only be used when it is absolutely necessary. Newborns exposed to clomipramine during pregnancy may experience withdrawal symptoms or side effects. Discuss the benefits and risks with your doctor, and inform them immediately if you notice jitteriness, shaking, feeding problems, fast breathing, or seizures in your newborn.

Since untreated mental/mood problems such as obsessive-compulsive disorder, depression, or panic attacks can be serious conditions, do not stop taking this medication unless directed by your doctor. If you are planning to become pregnant, are already pregnant, or think you may be pregnant, discuss the benefits and risks of using this medication during pregnancy with your doctor.

This medication passes into breast milk and may have adverse effects on a nursing infant. Speak to your doctor before breastfeeding.

Form and Strength

Anafranil is available in the following forms and strengths:

  • Anafranil tablet:

    • 10mg
    • 25mg
    • 50mg
  • clomipramine tablet:

    • 25mg
    • 50mg


How long does Anafranil take to work?

It may take 2 to 3 weeks or longer before the full effects of this medication are noticed.

Can I drink alcohol with Anafranil?

Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling.



Additional information

Generic name:





10mg, 25mg, 50mg

Quantities Available:

90, 100, 200

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Anafranil (Clomipramine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Anafranil (Clomipramine).