Depo Medrol Injection (Methylprednisolone acetate) Customer Reviews

Depo Medrol Injection

Rx Prescription Required    RxFormulation : Vial

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Methylprednisolone injection is indicated for the treatment of severe allergic reactions and the management of various medical conditions such as multiple sclerosis, lupus, gastrointestinal disease, and specific forms of arthritis. Methylprednisolone injection may be used in conjunction with other medications to alleviate symptoms associated with low corticosteroid levels.

Classified as a corticosteroid medication, methylprednisolone injection operates by replenishing the deficient corticosteroid levels in individuals, thereby compensating for the natural production of these steroids by the body. This medication mitigates swelling and redness while modulating the immune system’s functionality to address various medical conditions.

Uses and Dosage

Methylprednisolone injection is available in powder form, which needs to be mixed with a suitable liquid for intramuscular or intravenous administration. It is also provided as a suspension for injection, suitable for intramuscular, intra-articular, or intralesional use.

The specific dosage regimen will be determined based on your medical condition and individual response to treatment.

Administration of methylprednisolone injection can take place either in a hospital or medical facility, or you may be instructed to self-administer the medication at home. If self-administration is required, your healthcare provider will provide comprehensive instructions on the proper injection technique. Should any difficulties arise while using methylprednisolone injection, promptly consult your healthcare provider for guidance.

During the course of your treatment, your doctor may adjust the dosage of methylprednisolone injection to ensure that the lowest effective dose is administered. Modifications to the dosage may be necessary if you encounter significant physical stress due to factors such as surgery, illness, or infection. Inform your doctor about any improvements or deterioration in your symptoms, as well as any new illnesses or changes in your overall health status that occur during the treatment period.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • headache
  • dizziness
  • slowed healing of cuts and bruises
  • acne
  • thin, fragile, or dry skin
  • red or purple blotches or lines under the skin
  • skin depressions at the injection site
  • increased body fat or movement to different areas of your body
  • difficulty falling asleep or staying asleep
  • inappropriate happiness
  • extreme changes in mood changes in personality
  • extreme tiredness
  • depression
  • increased sweating
  • muscle weakness
  • joint pain
  • dizziness
  • irregular or absent menstrual periods
  • increased appetite
  • hiccups

Inform your healthcare provider immediately if you experience any serious side effects:

  • sore throat, fever, chills, cough, or other signs of infection
  • seizures
  • vision problems
  • swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
  • difficulty breathing or swallowing
  • shortness of breath
  • sudden weight gain
  • rash
  • hives
  • itching
  • confusion
  • abnormal skin patches in the mouth, nose, or throat
  • numbness, burning, or tingling in the face, arms, legs, feet, or hands


Prior to initiating methylprednisolone treatment, inform your healthcare provider or pharmacist about any known allergies to methylprednisolone, prednisone, or any other substances. This product may contain inactive ingredients that can elicit allergic reactions or other complications.

Before using this medication, discuss your medical history with your doctor or pharmacist, especially if you have a history of bleeding disorders, blood clotting problems, osteoporosis, diabetes, eye diseases, heart problems, high blood pressure, current or past infections, kidney disease, liver disease, mental or mood conditions, stomach or intestinal issues, or seizures.

This medication may cause dizziness. Consumption of alcohol or marijuana can intensify dizziness. Refrain from driving, operating machinery, or engaging in activities that require alertness until you can safely do so.

This medicine may lead to stomach bleeding. Regular alcohol consumption while using this medication may increase the risk of stomach bleeding. Limit your intake of alcoholic beverages.

Methylprednisolone can increase your susceptibility to infections or worsen existing infections. Avoid contact with individuals who have contagious infections that can easily spread, such as chickenpox, COVID-19, measles, or the flu.

Notify your healthcare professional about your use of methylprednisolone before undergoing any immunizations, vaccinations, or skin tests. Steer clear of individuals who have recently received live vaccines (such as the flu vaccine administered via nasal inhalation).

Prolonged use of corticosteroid medications can reduce your body’s ability to respond to physical stress. Prior to undergoing surgery or emergency treatment, or in the event of a severe illness or injury, inform your doctor or dentist about your current or past use of this medication within the past 12 months. Immediately inform your doctor if you experience unusual or extreme fatigue or weight loss. If you will be using this medication for an extended duration, carry a warning card or wear a medical ID bracelet that identifies your use of this medication.

Older adults may be more susceptible to the side effects of this medication, particularly bone loss/pain, stomach or intestinal bleeding, and mental or mood changes (such as confusion).

Long-term use of this medication in children may potentially slow down their growth. Ensure regular check-ups with the doctor to monitor your child’s height and growth.

During pregnancy, this medication should only be used when clearly necessary. It rarely poses a risk to the unborn baby. Discuss the potential risks and benefits with your doctor. Infants born to mothers who have used this medication for an extended period during pregnancy may experience hormone-related issues. Notify your doctor immediately if you observe symptoms such as persistent nausea or vomiting, severe diarrhea, or weakness in your newborn.

This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Form and Strength

Depo-Medrol is available in the following forms and strengths:

  • Depo-Medrol vial:

    • 20mg/ml


How long does an injection of Depo-Medrol last?

On average the effect of a single 2ml injection may be expected to last approximately two weeks.

How long does Depo-Medrol take to reduce inflammation?

Methylprednisolone works quickly, and you can expect to get relief from inflammation symptoms in 1-4 days.



Additional information

Generic name:

Methylprednisolone acetate




20mg/mL, 40mg/mL, 80mg/mL

Quantities Available:

2mL, 5mL

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Depo Medrol Injection (Methylprednisolone acetate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Depo Medrol Injection (Methylprednisolone acetate).