Domperidone functions as an antiemetic, countering nausea, and as a prokinetic agent, stimulating gut motility. It is classified within the dopamine antagonist category of pharmaceuticals. Employed to address gastric-related concerns, including nausea, vomiting, abdominal discomfort, and pain, it is particularly effective in cases where stomach and upper gastrointestinal (GI) tract movement is compromised.
Domperidone operates by inhibiting dopamine receptors within the gastrointestinal tract. This action augments the rhythmic contractions of stomach and intestinal muscles, expediting the movement of ingested food through the digestive passage.
Uses and Dosage
The standard adult dosage of domperidone is 10 mg, to be taken 15 to 30 minutes before meals. The maximum prescribed dose is 30 mg daily, for the briefest possible duration of treatment. Factors such as body weight, concurrent medical conditions, and concomitant medications can influence the requisite dosage for an individual.
In the event that your physician has recommended a dosage differing from those delineated here, do not alter your administration regimen without seeking counsel from your doctor.
Should a dose be missed, administer it at the earliest convenience and continue adhering to the established schedule. If the time for the subsequent dose is imminent, omit the missed dose and sustain the customary dosing timetable. Refrain from administering a double dose to compensate for a missed one. In case of uncertainty regarding the appropriate course of action following a missed dose, seek guidance from your doctor or pharmacist.
This medication should be stored at room temperature, shielded from light and moisture, and kept out of the reach of children.
Disposal of medications should not be executed via wastewater (e.g., sinks or toilets) or household refuse. To appropriately discard medications that are no longer required or have expired, consult your pharmacist for guidance.
Some side effects may occur that usually do not need medical attention:
- abdominal cramps
- breast pain
- dry mouth
Inform your healthcare provider immediately if you experience any serious side effects:
- breast milk flowing from the nipple
- fast, pounding, or racing heartbeat or pulse
- menstrual irregularities
- swelling of the breast (men)
- dizziness or fainting
- irregular heartbeat
- difficulty breathing, hives, swelling of the face or throat
Domperidone carries a heightened potential for heart rhythm irregularities and cardiac arrest. This hazard is particularly elevated among individuals aged 60 and above, as well as those consuming doses exceeding 30 mg daily. The risk escalates when combined with specific medications.
Inform your healthcare provider or pharmacist about any ongoing treatment for fungal or bacterial infections, as well as heart ailments or AIDS/HIV.
For adults and adolescents aged 12 years and above, weighing 35 kg or more, the employment of domperidone should be at the minimum effective dosage.
During the course of domperidone usage, if you encounter heart rhythm disturbances like palpitations, breathing difficulties, or loss of consciousness, promptly consult your doctor and cease domperidone treatment.
Should you be pregnant or contemplate pregnancy, apprise your doctor. In the event of pregnancy, an immediate discussion with your doctor is essential to evaluate the potential risks and benefits associated with this medication.
This medication permeates into breast milk. Prior to breastfeeding, consultation with your doctor is recommended.
Form and Strength
Motilium is available in the following forms and strengths:
What is Motilium used to treat?
Motilium is indicated for the relief of the symptoms of nausea and vomiting. Motilium should be used at the lowest effective dose for the shortest duration necessary to control nausea and vomiting.
Can Motilium be taken long term?
This medication is recommended for short-term use only. Motilium may be associated with an increased risk of heart rhythm disorder, particularly in older people.