Prescription Required 
Formulation : 
Description
Indications
Esomeprazole, in both prescription and over-the-counter forms, is utilized to treat various symptoms of gastroesophageal reflux disease (GERD) and other stomach-related conditions. Prescription esomeprazole is indicated for the treatment of GERD symptoms and related esophageal damage in adults and children as young as 1 year of age. It can prevent further damage and promote healing of the esophagus in GERD patients. Nonprescription esomeprazole is indicated for the treatment of frequent heartburn in adults. This medication works by reducing the amount of acid produced in the stomach, and it belongs to a class of medications known as proton pump inhibitors.
Uses and Dosage
Prescription esomeprazole is available as a delayed-release capsule, meant for oral consumption or administration through a feeding tube. It also comes in packets of delayed-release granules for suspension, which can also be taken orally or through a feeding tube.
Nonprescription esomeprazole is available as delayed-release capsules and tablets for oral intake.
Prescription esomeprazole is typically taken once a day at least 1 hour before a meal. In certain conditions characterized by excessive stomach acid production, it may be taken twice a day. Nonprescription delayed-release capsules and tablets are usually taken once daily in the morning, also at least 1 hour before eating, for a consecutive 14-day period. If necessary, additional 14-day treatments can be repeated, but not more frequently than once every 4 months.
Take esomeprazole at the same time(s) each day.
Follow the prescribed dosage precisely. Do not exceed or reduce the dose or frequency of administration without consulting your doctor or following the instructions on the package.
Swallow the capsules whole; do not split, chew, or crush them. If swallowing the capsule is difficult, empty the contents onto 1 tablespoon of cool, soft applesauce in a bowl and swallow the entire mixture immediately. Do not crush or chew the pellets in the applesauce, and avoid saving the mixture for later use.
If using the granules for suspension, mix them with water before consumption. Stir the mixture and drink it within 30 minutes. If any residue remains in the container, add more water, stir, and consume all of the mixture immediately.
Both the granules and the contents of the prescription delayed-release capsules can be administered through a feeding tube. Consult your doctor or pharmacist for specific instructions if you have a feeding tube, and follow them meticulously.
Do not use nonprescription esomeprazole for immediate relief of heartburn symptoms. It may take 1 to 4 days to experience the full benefits of the medication. Contact your doctor if your symptoms worsen, do not improve after 14 days, or recur sooner than 4 months after completing treatment. Do not use nonprescription esomeprazole for more than 14 days continuously or more frequently than once every 4 months without consulting your doctor.
Continue taking prescription esomeprazole as directed, even if you feel well. Notify your doctor if your symptoms worsen or do not improve. Do not discontinue esomeprazole without consulting your doctor.
Side Effects
Some side effects may occur that usually do not need medical attention:
- abdominal pain
- constipation
- decreased appetite
- diarrhea
- dry mouth or an unusual taste in the mouth
- flatulence
- headache
- nausea
Inform your healthcare provider immediately if you experience any serious side effects:
- acne
- blisters, peeling skin, hives, rashes or polyps
- changes in urination frequency or bloody urine
- difficulty breathing or irregular heartbeat
- dizziness, lightheadedness or excessive tiredness
- fever
- hoarseness or difficulty swallowing
- severe diarrhea or bloody stool
- severe nausea
- loss of appetite
- swelling, joint pain, muscle cramps or weakness
- uncontrollable shaking, jitteriness or seizures
Caution
- Before taking esomeprazole, inform your doctor or pharmacist if you are allergic to it, other proton pump inhibitors (PPIs) like lansoprazole or omeprazole, or if you have any other allergies. Inactive ingredients in the product may also trigger allergic reactions or other complications.
- Prior to using this medication, disclose your medical history to your doctor or pharmacist, especially if you have liver disease or lupus.
- Certain symptoms may indicate a more serious condition. Seek immediate medical assistance if you experience heartburn accompanied by lightheadedness, sweating, dizziness, chest, jaw, arm, or shoulder pain, especially if accompanied by shortness of breath, unusual sweating, or unexplained weight loss.
- Proton pump inhibitors (PPIs) such as esomeprazole may increase the risk of bone fractures, especially with prolonged use, higher doses, and in older adults. Consult your doctor or pharmacist about strategies to prevent bone loss and fractures, such as calcium and vitamin D supplementation.
- Older adults may be more susceptible to the side effects of this medication, particularly bone loss, fractures, and C. difficile infection. Children may also be more sensitive to certain side effects, such as fever, cough, and respiratory infections.
- During pregnancy, use this medication only when clearly necessary. Discuss the potential risks and benefits with your doctor.
- It is unclear whether this medication passes into breast milk, but similar drugs are known to do so. Consult your doctor before breastfeeding.
Form and Strength
Nexium Granules for Oral Suspension is available in the following forms and strengths:
- Nexium Granules for Oral Suspension sachet:
- 10 mg
FAQ
How long should I wait to eat after taking Nexium?
Nexium works best if you take it at least an hour before meals. This medication needs to be activated in your stomach before it can start working.
How long does it take for Nexium to take effect?
You should start to feel better within 2 to 3 days. It may take up to 4 weeks for Nexium to work properly. You may still have symptoms during this time.
Resources
- https://www.goodrx.com/esomeprazole/what-is#faqs
- https://www.mayoclinic.org/drugs-supplements/esomeprazole-oral-route/proper-use/drg-20074322
- https://www.webmd.com/drugs/2/drug-147599/nexium-packet-oral/details
- https://medlineplus.gov/druginfo/meds/a699054.html
- https://www.drugs.com/cdi/nexium-esomeprazole-powder-for-suspension.html
